Design and Simulation of High-throughput Microfluidic Droplet Dispenser for Lab-on-a-Chip Applications
نویسندگان
چکیده
Digital Microfluidic Biochips (DMFBs) have been widely used in Lab-on-a-Chip (LoC) for disease diagnosis and treatment applications. Biological sample to be processed are originally analog continuous flow. To convert it into digital droplets for DMFB processing, a microfluidic droplet dispenser acting as an analog-to-digital converter (ADC) is needed. In this paper, a highthroughput analog-to-digital microfluidic droplet dispenser is proposed. The proposed droplet dispenser has multiple digital output ports for parallel dispensing. COMSOL simulation is used to verify the function of the droplet dispenser. Multiphase flow model, laminar two-phase flow (tpf) and level set method are used in COMSOL simulation. The droplet dispenser can be used as interface between analog and digital microfluidic biochips.
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